Effects of rosmarinic acid on cognitive and biochemical alterations in ovariectomized rats treated with D-galactose

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GOK D., öztürk N., ER H., ASLAN M., DEMİR N., DERİN N., ...Daha Fazla

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, cilt.53, sa.4, ss.283-293, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5603/fhc.a2015.0034
  • Dergi Adı: FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.283-293
  • Anahtar Kelimeler: Alzheimer's disease, rat, estrogen deficiency, amyloid beta, rosmarinic acid, lipid peroxidation, COX-2, PGE2, short-term memory, hippocampus, electron microscopy, IHC, ALZHEIMERS-DISEASE, LIPID-PEROXIDATION, OXIDATIVE DAMAGE, SALVIA-OFFICINALIS, REPLACEMENT THERAPY, PROSTAGLANDIN E-2, MEMORY LOSS, ESTROGEN, MODEL, SAGE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction. Animal models designed to mimic certain features of Alzheimer's disease (AD) can help us to increase our understanding of the underlying mechanisms of disease. Previous studies have revealed that long-term D-galactose injection combined with ovariectomy results in pathophysiologic alterations associated with AD. Thus, the aim of the present study was to investigate the effects of rosmarinic acid (RA) administration on pathological changes associated with ovariectomy and D-galactose injection, which serve as a two-insult model for AD.