Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration

SAHIN M., Karauzum S., PERRY G., SMITH M., ALICIGUZEL Y.

NEUROTOXICITY RESEARCH, cilt.7, sa.3, ss.243-250, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/bf03036453
  • Dergi Adı: NEUROTOXICITY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.243-250
  • Anahtar Kelimeler: apoptosis, all-trans retinoic acid, 9-cis retinoic acid, 13-cis retinoic acid, amyloid-beta, hippocampal neurons, ALVEOLAR EPITHELIAL-CELLS, ALZHEIMERS-DISEASE, DEGENERATING NEURONS, LIPID-PEROXIDATION, INDUCED APOPTOSIS, OXIDATIVE STRESS, IN-VITRO, ACTIVATION, PEPTIDE, PROLIFERATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Attenuating amyloid-beta mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-beta mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-beta-induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.