Assessment of tumors in children with tuberous sclerosis: a single centre's experience

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Emir S., Hacisalihoglu S., Ozyoruk D., Ekici F., Degerliyurt A., Guven A., ...Daha Fazla

TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS, cilt.52, sa.1, ss.30-34, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/turkpediatriars.2017.4309
  • Dergi Adı: TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.30-34
  • Anahtar Kelimeler: Angiomyolipoma, rhabdomyoma, subependymal giant cell astrocytoma, tuberosclerosis, tumor, COMPLEX, PREVALENCE, POPULATION, DIAGNOSIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aim: As a result of mutations in TSC1 (9q34) and TSC2 (16p13.3) tumor supressor genes, the mammalian target of the rapamycin (mTor) signaling pathway is overactivated in patients with tuberous sclerosis. Abnormal cell proliferation and differentiation is responsible for the growth several different tumors. The aim of this study was to review tumors in our patients with tuberous sclerosis.