Massive pulmonary embolism and acute renal failure in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome: A case report

ÇETİNKAYA R., Odabaş A. R., Selçuk Y., karakuzu A., Varoğlu E., Ak C., ...Daha Fazla

PAIN CLINIC, cilt.14, sa.1, ss.89-91, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1163/156856902760189241
  • Dergi Adı: PAIN CLINIC
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-91
  • Anahtar Kelimeler: antiphospholipid syndrome, pulmonary embolism, systemic lupus erythematosus, ANTIBODIES, NEPHRITIS, LUNG
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

A 50 year old, previously healthy woman came to our attention with high fever, arthralgia and oliguria. Serological tests were positive for antinuclear antibodies, anti-double-stranded-DNA antibodies and cardiolipin antibodies. Renal histology indicated diffuse proliferative lupus nephritis. Three days after the hospitalisation, the patient developed massive pulmonary embolism and dialysis-dependent acute renal failure, for which she was dialysed. Heparin 1000 U/hour (7 days), methylprednisolone (1000 mg/day for 3 days) and cyclophosphamide (500 mg for one day) were administered. This therapy led to a dramatic improvement of renal and pulmonary functions and, consequently, treatment with hemodialysis could be stopped after 3 weeks. This case illustrates an uncommon manifestation of systemic lupus erythematosus associated with antiphospholipid syndrome.