Assessment of arterial stiffness for clinical and epidemiological studies: methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry

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Boutouyrie P., Fliser D., Goldsmith D., Covic A., Wiecek A., Ortiz A., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.29, sa.2, ss.232-239, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1093/ndt/gft309
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.232-239
  • Anahtar Kelimeler: aortic pressure, arterial stiffness, elastic modulus, pulse-wave velocity, PULSE-WAVE VELOCITY, ALL-CAUSE MORTALITY, EXPERT CONSENSUS DOCUMENT, CHRONIC KIDNEY-DISEASE, AORTIC STIFFNESS, INDEPENDENT PREDICTOR, HEMODIALYSIS-PATIENTS, OLDER-ADULTS, RISK-FACTORS, PRESSURE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Epidemiological studies have highlighted the role of arterial stiffness as a risk factor for development of cardiovascular (CV) diseases. Moreover, aortic stiffness has been shown to be a significant predictive factor of all-cause and CV mortality in different populations including patients with end-stage renal disease. Pulse-wave velocity (PWV) is the most widely used technique to assess arterial stiffness. Although PWV can be measured on any artery or between any arterial sites, only carotid-to-femoral PWV, representing stiffness of the aorta and iliofemoral axes, has been shown to have predictive value for morbidity and mortality. The several available commercial devices differ according to the type of signal (pressure, distension, flow) or by recording both sites simultaneously or using ECG synchronization. It is also possible to directly measure arterial diameter changes during the cardiac cycle and link them to local pulse-pressure changes, which provides the pressure-diameter relationship and stress-strain relationship if arterial wall thickness is also measured. These techniques are based on high-precision vascular echo tracking or magnetic resonance imaging and applanation tonometry. This paper summarizes the basic principles of arterial haemodynamics and various methodologies to assess stiffness and the latest consensus recommendations for clinical applications.