Oxidative stress and apoptosis: impact on cancer therapy

Ozben T.

JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.96, sa.9, ss.2181-2196, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 96 Sayı: 9
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/jps.20874
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2181-2196
  • Anahtar Kelimeler: cancer chemotherapy, cancer, cell lines, oxidation, oligonucleotides, multidrug resistance, DRUG-INDUCED APOPTOSIS, VITAMIN-E SUCCINATE, APO-1/FAS RECEPTOR/LIGAND SYSTEM, PROGRAMMED CELL-DEATH, OXYGEN SPECIES ROS, NITRIC-OXIDE, LIPID-PEROXIDATION, IN-VITRO, ANTIOXIDANT TEMPOL, LEUKEMIA-CELLS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

It is well established that some chemotherapeutic agents and radiation therapy generate reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly ROS have been proposed as common mediators for apoptosis. Recent studies have demonstrated that the mode of cell death depends on the severity of the oxidative damage. This review will address some of the current paradigms of oxidative stress, and antioxidants on apoptosis, and discuss the potential mechanisms by which oxidants can regulate apoptotic pathways. It will also review new developments in eliminating cancer cells by selectively inducing apoptosis. (c) 2007 Wiley-Liss, Inc.