Gentamicin-Induced Acquired Bartter-Like Syndrome: A Case Report and Review of the Literature

Yilmaz F., Boraz F., Ersoy F. F.

TURKISH JOURNAL OF NEPHROLOGY, cilt.28, sa.4, ss.324-327, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/turkjnephrol.2019.3510
  • Dergi Adı: TURKISH JOURNAL OF NEPHROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.324-327
  • Anahtar Kelimeler: Gentamicin, aminoglycosides, acquired Bartter-like syndrome, ALKALOSIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aminoglycosides are a group of antibiotics commonly used in the treatment of serious gram-negative bacterial infections. We report a case of acquired Bartter-like syndrome (ABLS) observed following gentamicin treatment for acute infective exacerbation of chronic lung disease. A 38-year-old male was admitted with sudden-onset, rapid symmetrical flaccid weakness in the proximal lower-extremity muscles. His history was remarkable for an acute infective exacerbation of chronic pulmonary disease 11 days before, treated with intravenous amoxicillin/clavulanic acid and gentamicin. The patient paralyzed due to hypokalemia. He was diagnosed with aminoglycosides-induced ABLS. He was managed with potassium and calcium supplements given intravenously for 1 week, followed by 3 weeks of oral administration for both. ABLS induced by gentamicin has rarely been documented in the literature. Early diagnosis and adequate treatment can ensure a good prognosis.