The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia

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ÖZTÜRK S., Sozen B., UYSAL F., Bassorgun I. C., USTA M. F., AKKOYUNLU G., ...Daha Fazla

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.33, sa.3, ss.335-348, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10815-016-0654-z
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.335-348
  • Anahtar Kelimeler: Male infertility, Non-obstructive azoospermia, EPAB, PABPC1, PABPC3, POLY(A) BINDING-PROTEIN, TRANSLATIONAL REGULATION, SPERMATOGENIC CELLS, MESSENGER-RNAS, DEADENYLATION, SPERMIOGENESIS, IDENTIFICATION, MATURATION, STAGE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose Azoospermia is one of the major causes of male infertility and is basically classified into obstructive (OA) and non-obstructive azoospermia (NOA). The molecular background of NOA still largely remains elusive. It has been shown that the poly(A)-binding proteins (PABPs) essentially play critical roles in stabilization and translational control of the mRNAs during spermatogenesis.