Major pathways of the reno-cardiovascular link: the sympathetic and renin-angiotensin systems

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Blankestijn P. J., London G., Fliser D., Jager K. J., Lindholm B., Goldsmith D., ...Daha Fazla

KIDNEY INTERNATIONAL SUPPLEMENTS, cilt.1, sa.1, ss.13-16, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 1 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1038/kisup.2011.3
  • Dergi Adı: KIDNEY INTERNATIONAL SUPPLEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-16
  • Anahtar Kelimeler: chronic kidney disease, hypertension, renin angiotensin, sympathetic activity
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Chronic kidney disease is often characterized by enhanced activity of the renin-angiotensin system (RAS) and the sympathetic nervous system. Independent of their effect on blood pressure, these systems also contribute to the pathogenesis of both structural and functional cardiovascular abnormalities and contribute importantly to clinical outcome. There is much evidence that the diseased kidneys are of central importance in the pathogenesis of both abnormalities. Inhibitors of the RAS also reduce sympathetic overactivity. Future research should be aimed at addressing the pathophysiological mechanisms causing the enhanced activities. Given the fact that even a small kidney lesion can cause enhanced activity of the RAS and the sympathetic nervous system, it is likely that these pathophysiological mechanisms are operational in more disease conditions, including essential hypertension, heart failure, and obesity/metabolic syndrome.