Protective effects of minocycline on experimental spinal cord injury in rats

Aras M., Altas M., Motor S., Dokuyucu R., Yilmaz A., ÖZGİRAY E., ...Daha Fazla

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.46, sa.8, ss.1471-1474, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.injury.2015.05.018
  • Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1471-1474
  • Anahtar Kelimeler: Spinal cord injury, Minocycline, Antioxidant activity, Experimental study, CYTOCHROME-C RELEASE, LIPID-PEROXIDATION, MODEL, MELATONIN, RECOVERY, DEATH, MICE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: The effects of minocycline on neuronal injury after spinal cord injury (SCI) are limited and controversial. Therefore we aimed to investigate the protective effects of minocycline on tissue and on serum concentrations of malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, tissue total antioxidant and oxidant status (TAS and TOS, respectively), and AST and LDH levels in rats with SCI.