Effect of cadmium on antioxidant status in alloxane-induced diabetic rats

Gumuslu S., Yargicoglu P., Agar A., Edremitlioglu M., Alıcıgüzel Y.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.57, sa.2, ss.105-114, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1007/bf02778193
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.105-114
  • Anahtar Kelimeler: cadmium, selenium, vitamin E, ceruloplasmin, rat, GLUTATHIONE-PEROXIDASE ACTIVITIES, RED-CELL LIPIDS, VITAMIN-E, SELENIUM SUPPLEMENTATION, BIOCHEMICAL PARAMETERS, ASCORBIC-ACID, GROWING-RATS, SERUM, PLASMA, BLOOD
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Fifty-two healthy Swiss Male Albino rats aged two mo were used in this study. They were divided into four groups: control (C), diabetic (D), cadmium (Cd), and diabetic + Cd (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 ip (2 mg/kg/wk). At the end of the 2-mo experimental period, thiobarbituric acid reactive substances (TEARS), plasma and erythrocyte selenium (Se), plasma ceruloplasmin (Cp), and vitamin E (vit E) were determined in four groups of rats.