A case of primary Sjogren's syndrome with pulmonary-limited Wegener's granulomatosis

YAZISIZ V., ÖZBUDAK İ. H., Nizam I., Erbasan F., Avci A. B., ÖZBUDAK Ö., ...Daha Fazla

RHEUMATOLOGY INTERNATIONAL, cilt.30, sa.9, ss.1235-1238, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00296-009-1045-x
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1235-1238
  • Anahtar Kelimeler: Antineutrophil cytoplasmic antibody (ANCA), Sjogren's syndrome, Wegener's granulomatosis, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, CLASSIFICATION, PREVALENCE, DISEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

A 60-year-old woman had a history of dyspnea for 5-6 weeks. The chest radiograph and computed tomography scans revealed bilateral patchy reticulonodular pattern. The patient had positive test results for antineutrophil cytoplasmic antibody against proteinase-3 (c-ANCA), antinuclear antibody and anti-Ro antibody. According to European Study Group on Classification Criteria for Sjogren's Syndrome, the patient was diagnosed as primary Sjogren's syndrome based on the presence of clinical features, positive findings on Schirmer's test and parotis scintigraphy. Lung biopsy obtained by wedge resection showed granulomatous inflammation with extensive multinuclear giant cells involving the lung parenchyma and vascular structures. There was neither upper airway nor renal involvement. Thus, the patient was simultaneously diagnosed as pulmonary-limited Wegener's granulomatosis. With this unique case, we would like to emphasize that the awareness of ANCA-associated vasculitis as a diagnostic possibility in primary Sjogren's syndrome is important during the work-up of lung lesions.

A 60-year-old woman had a history of dyspnea for 5-6 weeks. The chest radiograph and computed tomography scans revealed bilateral patchy reticulonodular pattern. The patient had positive test results for antineutrophil cytoplasmic antibody against proteinase-3 (c-ANCA), antinuclear antibody and anti-Ro antibody. According to European Study Group on Classification Criteria for Sjogren's Syndrome, the patient was diagnosed as primary Sjogren's syndrome based on the presence of clinical features, positive findings on Schirmer's test and parotis scintigraphy. Lung biopsy obtained by wedge resection showed granulomatous inflammation with extensive multinuclear giant cells involving the lung parenchyma and vascular structures. There was neither upper airway nor renal involvement. Thus, the patient was simultaneously diagnosed as pulmonary-limited Wegener's granulomatosis. With this unique case, we would like to emphasize that the awareness of ANCA-associated vasculitis as a diagnostic possibility in primary Sjogren's syndrome is important during the work-up of lung lesions.