Dose-dependent effect of nutritional sulfite intake on visual evoked potentials and lipid peroxidation

Ozturk N., Yargicoglu P., DERİN N., Akpinar D., Agar A., Aslan M.

NEUROTOXICOLOGY AND TERATOLOGY, cilt.33, sa.2, ss.244-254, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ntt.2010.09.002
  • Dergi Adı: NEUROTOXICOLOGY AND TERATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.244-254
  • Anahtar Kelimeler: Sulfite, Visual evoked potentials, Lipid peroxidation, SULFUR-DIOXIDE INHALATION, OXIDASE DEFICIENT RATS, SODIUM METABISULFITE, ANTIOXIDANT STATUS, ENZYME-ACTIVITIES, AIR-POLLUTION, GUINEA-PIGS, EXPOSURE, GLUTATHIONE, OXIDATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of this study was to clarify the dose-dependent effect of sulfite (SO32-) ingestion on brain and retina by means of electrophysiological and biochemical parameters. Fifty two male Wistar rats, aged 3 months, were randomized into four experimental groups of 13 rats as follows; control (C), sulfite treated groups (S-1; 10 mg/kg/day, S-2:100 mg/kg/day, S-3; 260 mg/kg/day). Control rats were administered distilled water, while the other three groups were given sodium metabisulfite (Na2S2O5) of amounts mentioned above, via gavage for a period of 35 days.