The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma

Altas M., Bayrak O. F., AYAN E., BOLUKBASI F., SILAV G., COSKUN K. K., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, sa.9, ss.1611-1617, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-010-0671-0
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1611-1617
  • Anahtar Kelimeler: Hypophyseal adenoma, MMP, Genome, Promoter region, SINGLE NUCLEOTIDE POLYMORPHISM, HUMAN PITUITARY-TUMORS, MATRIX METALLOPROTEINASES, DURAL INVASION, EXPRESSION, TRANSCRIPTION, COLLAGENASE, CANCER, CARCINOMA, BINDING
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

The matrix metalloproteinase-1 enzyme (MMP-1, also called collagenase 1) plays a key role in turnover of collagen fibers in the intercellular matrix. Insertion of a guanine residue was found within the promoter region of the MMP-1 gene. We found that MMP-1 levels increased approximately twofold over normal when this insertion was present, enabling MMP-1 to facilitate tumor invasion and metastasis. MMP-1 is also believed to play a role in tumor development. The aim of our study is to investigate the effect of polymorphisms in the promoter region of the MMP-1 gene on the development of benign and invasive hypophyseal adenomas.