Diffuse Thymic Fibrosis Histologic Pattern of Injury or Distinct Entity?

SHILO K., MANI H., DESHPANDE C., ÖZBUDAK İ. H., TRAVIS W. D., GALVIN J. R., ...Daha Fazla

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, cilt.34, sa.2, ss.211-215, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/pas.0b013e3181c91301
  • Dergi Adı: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.211-215
  • Anahtar Kelimeler: thymus, thymic fibrosis, fibrosing mediastinitis, hyalinizing granuloma, IgG4, myasthenia gravis, PULMONARY HYALINIZING GRANULOMA, DESMOID TUMOR, PSEUDOTUMOR, THYMOMA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Thymic fibrosis in the absence of another primary thymic lesion, such as a neoplasm or cyst, is Unusual. We identified 6 cases of primary extensive thymic fibrosis that developed in 3 men and 3 women, aged 28 to 60 years, mean 48 years. Patients had limited or no symptoms. Two patients had dyspnea and 1 had cough and hemoptysis. One female patient had myasthenia gravis. The lesions measured 3.5 to 17 cm in greatest dimension, mean 8 cm, and were confined to the anterior mediastinum its determined by imaging, intraoperative notes, and/or gross examination. All cases showed diffuse fibrosis with variable collagen deposition, lymphoplasmacytic infiltrates, and involution/atrophy of thymus. One case had rare IgG4-positive plasma cells and focal obliterative phlebitis. The histology showed overlap with that of IgG4-related sclerosing disease, which to our knowledge has not been documented earlier in this location. Although the etiology of the lesions is undetermined, altered immunity and/or infection may play a role.