The importance of COX-2 expression as prognostic factor in early breast cancer

Kargi A., Uysal M., Bozcuk H., COŞKUN H. Ş., Savas B., Ozdogan M.

JOURNAL OF BUON, cilt.18, sa.3, ss.579-584, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 3
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.579-584
  • Anahtar Kelimeler: breast cancer, COX-2, cyclooxygenase system, prognostic factors, CYCLOOXYGENASE-2 EXPRESSION, AROMATASE, CELLS, INHIBITION, GROWTH
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: A number of studies have been carried out, showing that the risk for breast carcinoma is decreased in those using non-steroidal anti-inflammatory drugs (NSAIDs). Increased cyclooxygenase-2 (COX-2) level is considered as a factor indicating poor prognosis and responsible for angiogenesis, increased cellular proliferation, apoptotic defect and aromatase enzyme induction. For this reason the level of COX-2 might have a prognostic and predictive value in breast cancer as well. This question has become the basis of the present study.