Glutathione S-Transferase M1, GSTT1 and GSTP1 Genetic Polymorphisms and the Risk of Age-Related Macular Degeneration

Guven M., Gorgun E., ÜNAL M., Yenerel M., Batar B., Kucumen B., ...Daha Fazla

OPHTHALMIC RESEARCH, cilt.46, sa.1, ss.31-37, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1159/000321940
  • Dergi Adı: OPHTHALMIC RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.31-37
  • Anahtar Kelimeler: Glutathione S-transferase, Polymorphism, Age-related macular degeneration, MANGANESE SUPEROXIDE-DISMUTASE, RETINAL-PIGMENT EPITHELIUM, COMPLEMENT FACTOR-H, OXIDATIVE STRESS, TURKISH POPULATION, SUPERGENE FAMILY, DNA-DAMAGE, CANCER, GENOTYPES, GSTM1
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD). Patients and Methods: This case-control study included a total of 120 patients with AMD (65 with dry-type AMD and 55 with wet-type AMD) and 198 disease-free controls. GSTM1 and GSTT1 polymorphisms were analyzed by using a multiplex polymerase chain reaction (PCR), and GSTP1 polymorphism was detected by real-time PCR assay. Results: GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.82, 95% CI = 1.14-2.91). Stratification by AMD subtypes revealed a significant relationship between GSTM1-null genotype and dry-type AMD (p = 0.02, OR = 1.98, 95% CI = 1.10-3.53). In a stepwise regression model, only GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.77, 95% CI = 1.11-2.81). Conclusions: Our findings suggest that genetic polymorphisms of GST may have a role in the development of AMD. Copyright (C) 2011 S. Karger AG, Basel