The effect of cetirizine on IFN-gamma and IL-10 production in children with allergic rhinitis

UGUZ A., Sanlioglu S., YUZBEY S., COSKUN M., Yegin O.

TURKISH JOURNAL OF PEDIATRICS, cilt.47, sa.2, ss.111-115, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2005
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.111-115
  • Anahtar Kelimeler: allergic rhinitis, cetirizine, IFN-gamma, IL-10, IL-4, CELLS, INTERLEUKIN-5, THERAPY, SAFETY, DRUG
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Cetirizine, one of the most commonly used antihistamines for the treatment of allergic diseases, possesses some anti-inflammatory properties. Despite its common use, the effect of cetirizine on the production of cytokines from peripheral blood mononuclear cells (PBMCs) needs further clarification. The aim of this study was to investigate whether cetirizine changes interleukin (IL)-10, (IF)-gamma and IL-4 production from PBMCs in children with allergic rhinitis.