Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG)

GUVEN M., Unal M., BATAR B., EROGLU E., DEVAROGLU K., TAMCELIK N., ...Daha Fazla

MOLECULAR VISION, cilt.13, sa.1-2, ss.12-17, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 1-2
  • Basım Tarihi: 2007
  • Dergi Adı: MOLECULAR VISION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.12-17
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: Oxidative DNA damage has been shown to have some role in the development of primary open angle glaucoma (POAG). In this study, we aimed to determine the frequency of polymorphisms in two DNA repair enzyme genes, Xeroderma pigmentosum complementation group D (XPD) codon 751 and X-ray cross-complementing group 1 (XRCC1) codon 399, in a sample of Turkish patients with POAG, and to evaluate their association with POAG development.