Changes in expressions of ADAM9, 10, and 17 as well as alpha-secretase activity in renal cell carcinoma

ERİN N., Ipekci T., AKKAYA B., Ozbudak I. H., Baykara M.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.35, sa.1, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.urolonc.2016.08.010
  • Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: alpha-Secretase, ADAM10, ADAM9, ADAM17, Renal cell carcinoma, Human, PANCREATIC DUCTAL ADENOCARCINOMA, AMYLOID PRECURSOR PROTEIN, MESSENGER-RNA EXPRESSION, CONVERTING-ENZYME, GROWTH-FACTOR, GENE-EXPRESSION, BREAST-CANCER, TUMOR-SUPPRESSOR, FACTOR-RECEPTOR, UP-REGULATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: ADAM9, 10, and 17 are a class of disintegrins and metallproteinases with oc-secretase activity. There are conflicting results regarding the role(s) of ADAM9, 10, and 17 in carcinogenesis, and only a few studies have examined their levels and cellular localization in renal cell carcinoma (RCC). Studies examining changes in oc-secretase activity in RCC compared to enzymatic activity of the uninvolved kidney are lacking.