Thiol redox homeostasis in neurodegenerative disease

McBean G. J., AYDIN ASLAN M., Griffiths H. R., Torrao R. C.

REDOX BIOLOGY, cilt.5, ss.186-194, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.redox.2015.04.004
  • Dergi Adı: REDOX BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.186-194
  • Anahtar Kelimeler: Cysteine, Glutathione, Thioredoxin, Glutaredoxin, Peroxiredoxin, Neurodegenerative disease, PRIMARY-OPEN-ANGLE, PEROXIREDOXIN 6 OVEREXPRESSION, CYSTATHIONINE-GAMMA-LYASE, GLUTATHIONE LEVELS OCCURS, NEURONAL CELL-DEATH, OXIDATIVE STRESS, ALZHEIMERS-DISEASE, BRAIN MITOCHONDRIA, SYSTEM X(C)(-), CYSTINE/GLUTAMATE ANTIPORTER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the x(c)(-) cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).