Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice

Gungor-Ordueri N. E., KUŞCU N., TAŞATARGİL A., Burgucu D., Karacan M., ÇELİK ÖZENCİ Ç.

PHARMACOLOGICAL REPORTS, cilt.71, sa.4, ss.591-602, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.pharep.2019.02.018
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.591-602
  • Anahtar Kelimeler: Doxorubicin, PARP-1, PJ34, Apoptosis, Testicular damage, Male infertility, DIABETIC ENDOTHELIAL DYSFUNCTION, INDUCED OXIDATIVE STRESS, ADP-RIBOSE POLYMERASE, POLY(ADP-RIBOSE) POLYMERASE, PHARMACOLOGICAL INHIBITION, CYTOCHROME-C, CELL-DEATH, APOPTOSIS, SYNTHETASE, PROTECTION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Doxorubicin (DOX), is a chemotherapeutic agent, which evokes oxidative stress and cell apoptosis in testicular tissue. It is known that the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP), leading to apoptosis induced by DOX. The aim of the present study is to investigate whether PARP pathway has a role in DOX-induced testicular damage and infertility utilizing pharmacological PARP-1 inhibitor, PJ34, and PARP-1 knockout mice model.