Investigation of Antibacterial Effects of Streptomycin Sulfate-Loaded PMMA/PEO/Bis-Chalcone Derivatives-Based Fibers

Koçer K. N., Nohut Maşlakçi N., Eren E., Çevikbaş H., Ulusoy S., Biçer A., ...Daha Fazla

International Joint Science Congress of Materials and Polymers (ISCMP), Burdur, Türkiye, 29 Eylül - 01 Kasım 2021, ss.122

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Burdur
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.122
  • Akdeniz Üniversitesi Adresli: Evet

Özet

In this study, fibers were obtained by electrospinning technique to increase the bioavailability of biocompatible polymethyl methacrylate (PMMA)/polyethylene oxide (PEO)/bis-chalcone derivatives ((2E,6E)‐2,6‐bis(4-nitrobenzylidene)cyclohexanone and (2E,6E)‐2,6‐bis[(thiophen‐2‐yl)methylene]cyclohexanone) containing Streptomycin sulfate as a model drug in two different ratios (30 and 60 mg). The antibacterial effects of drug-containing and non-drug fibers against Bacillus cereus and Escherichia coli were investigated. As a result, it was observed that the drug-free fibers did not have any antibacterial effect, while the drug-containing fibers completely destroyed B. cereus and E. coli. Our findings can provide insight into new fibers prepared with antimicrobial compounds for wound dressing applications.