Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women

YILDIZ M., Kumru S., GODEKMERDAN A., KUTLU S.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, cilt.90, sa.2, ss.128-133, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.ijgo.2005.05.005
  • Dergi Adı: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.128-133
  • Anahtar Kelimeler: hormone therapy, estradiol valerate, dienogest, raloxifene, soy isoflavones, high-sensitive C-reactive protein, ESTROGEN REPLACEMENT THERAPY, PLUS PROGESTIN, INFLAMMATION, PREVENTION, DISEASE
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Objective: To compare the effects of raloxifene, estradiol valerate plus dienogest, and soy isoflavones (genistein) on serum concentrations of high-sensitive C-reactive protein in healthy postmenopausal women. Methods: The 80 healthy postmenopausal women enrolled in the study were randomly allocated to receive 60 mg of raloxifene, 2 mg of estradiol valerate plus dienogest, 40 mg of genistein, or placebo (n = 20 in each group). Blood samples were collected at the start of the study and at 3 and 6 months. Lipid profile was also determined. Results: Only the group receiving estradiol valerate plus dienogest showed an increase in serum Levels of high-sensitive C-reactive protein compared with baseline values and values in the control and other groups. All 3 treatments resulted in an increase in high-density lipoprotein cholesterol levels and a decrease in total, tow-density, and very-low-density lipoprotein cholesterol levels. Conclusions: Estradiol valerate plus dienogest, but not raloxifene and genistein, increase serum high-sensitive C-reactive protein levels. All 3 treatments, however, have an estrogen-like effect on serum lipid profile. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.