Effect of glucocorticoids on mechanisms of placental angiogenesis

Ozmen A., Unek G., KORGUN E. T.

PLACENTA, cilt.52, ss.41-48, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.placenta.2017.02.015
  • Dergi Adı: PLACENTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-48
  • Anahtar Kelimeler: Glucocorticoids, Placenta, Angiogenesis, Human, Rat, HUMAN FETOPLACENTAL VASCULOGENESIS, GROWTH-FACTOR EXPRESSION, UMBILICAL ARTERY, 11-BETA-HYDROXYSTEROID DEHYDROGENASE, ANTENATAL CORTICOSTEROIDS, SYNTHETIC GLUCOCORTICOIDS, PRENATAL STRESS, BLOOD-PRESSURE, LATE PREGNANCY, PRETERM BIRTH
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The benefits of antenatal glucocorticoid (GC) treatment to promote human fetal lung maturation are well established. However, reports have emerged indicating that maternal exposure to high concentrations of circulating GCs alters placental and fetal development. Because many adult-onset metabolic and cardiovascular disorders have their origins in utero, the importance of prenatal conditions should be considered in detail. Therefore, this review aims to present an overview of the GC effect on placental and fetal development, specifically with regard to mechanisms of placental angiogenesis.