The effects of short-term nifedipine treatment on responsiveness of aortic rings of cadmium-hypertensive rats

Ozdem S. S., OGUTMAN C.

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.21, sa.4, ss.423-440, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 1999
  • Doi Numarası: 10.3109/10641969909068674
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.423-440
  • Anahtar Kelimeler: cadmium, hypertension, nifedipine, rat, VASCULAR REACTIVITY, CALCIUM-ANTAGONISTS, ENDOTHELIN-1, FELODIPINE, RESPONSES, COMBINATION, MECHANISMS, RECEPTORS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The effects of short-term antihypertensive treatment with nifedipine on blood pressure and vascular responsiveness were studied in cadmium-hypertensive and normotensive control rats. Cadmium administration caused a significant increase in mean arterial blood pressure. Endothelin-1, noradrenaline and angiotensin II produced concentration dependent contractions of aortic rings that attained a lower maximal contraction in cadmium-hypertensive rats. Responses of aortic rings to KCl did not show a significant difference between the groups. Nifedipine administered simultaneously with cadmium inhibited the induction of hypertension. Nifedipine treatment for 5 days significantly reduced the blood pressure in cadmium-hypertensive and normotensive rats. Neither inhibition of hypertension nor normalization of blood pressure in cadmium-hypertensive rats caused an alteration in contractile responses of aortic rings to vasoconstrictors which suggested that development of decreased vascular reactivity and of hypertension occurs simultaneously in cadmium-hypertensive rats but the role of decreased vascular reactivity in maintenance of hypertension is questionable in cadmium-hypertension.