The effect of atorvastatin treatment on insulin resistance, leptin, and highly sensitive C-reactive protein in hypercholesterolemic patients

SARI R., Eray E.

ENDOCRINOLOGIST, cilt.17, sa.6, ss.315-317, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1097/ten.0b013e31815ecdce
  • Dergi Adı: ENDOCRINOLOGIST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.315-317
  • Anahtar Kelimeler: hypercholesterolemia, statin, leptin, high sensitive C-reactive protein, insulin resistance, SIMVASTATIN, PRAVASTATIN, THERAPY, DISEASE, RISK
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the effect of atorvastatin treatment on insulin resistance, highly sensitive C-reactive protein, and leptin levels in hypercholesterolemic patients. Forty-two hypercholesterolemic and 24 control subjects were included in this study. Serum lipids, insulin, glucose, leptin, highly sensitive C-reactive protein, and homeostasis model assessment (HOMA-IR) were determined at baseline and after 3 months' atorvastatin treatment. Only high sensitive C-reactive protein level was decreased after treatment with atorvastatin in patients with hypercholesterolemia. These findings suggest that atorvastatin may be used as a therapy for improving the plasma lipids profile, as well as the chronic low-grade inflammatory state, in hypercholesterolemia.