Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache

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Bellei E., Monari E., CUOGHI A., Bergamini S., Guerzoni S., CICCARESE M., ...Daha Fazla

JOURNAL OF HEADACHE AND PAIN, cilt.14, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/1129-2377-14-6
  • Dergi Adı: JOURNAL OF HEADACHE AND PAIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Medication-overuse headache, Proteomics, NSAIDs, Nephrotoxicity, SELDI-TOF-MS, Two-dimensional gel electrophoresis, ACID-BINDING PROTEIN, URINARY PROTEOMICS, BETA-2-MICROGLOBULIN, SERUM, COMBINATION, ALBUMIN, MARKER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Medication-overuse headache (MOH) is a chronic headache condition that results from the overuse of analgesics drugs, triptans, or other antimigraine compounds. The epidemiology of drug-induced disorders suggests that medication overuse could lead to nephrotoxicity, particularly in chronic patients. The aim of this work was to confirm and extend the results obtained from a previous study, in which we analyzed the urinary proteome of 3 MOH patients groups: non-steroidal anti-inflammatory drugs (NSAIDs), triptans and mixtures abusers, in comparison with non-abusers individuals (controls).