Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential

Lang I., Schweizer A., Hiden U., Ghaffari-Tabrizi N., Hagendorfer G., Bilban M., ...Daha Fazla

DIFFERENTIATION, cilt.76, sa.10, ss.1031-1043, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1432-0436.2008.00302.x
  • Dergi Adı: DIFFERENTIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1031-1043
  • Anahtar Kelimeler: placenta, arteries, veins, fetal endothelium, differentiation, SMOOTH-MUSCLE-CELLS, HUMAN TERM PLACENTA, STEM-CELLS, VASCULAR MORPHOGENESIS, MOLECULAR DISTINCTION, LYMPHATIC VESSEL, HETEROGENEITY, ANGIOGENESIS, EXPRESSION, PREGNANCY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Growing interest in the sources of origin of blood vessel related diseases has led to an increasing knowledge about the heterogeneity and plasticity of endothelial cells lining arteries and veins. So far, most of these studies were performed on animal models. Here, we hypothesized that the plasticity of human fetal endothelial cells depends on their vascular bed of origin i.e. vein or artery and further that the differences between arterial and venous endothelial cells would extend to phenotype and genotype.