Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia

Cetin Z., Tezcan G., Karauzum S. B., Kupesiz A., Manguoglu A. E., Yesilipek A., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.28, sa.11, ss.763-767, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1097/01.mph.0000243660.48808.72
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.763-767
  • Anahtar Kelimeler: JMML, donor cell leukemia, stem cell transplantation, BONE-MARROW-TRANSPLANTATION, ACUTE MYELOID-LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, ACUTE LYMPHOBLASTIC-LEUKEMIA, CYTOGENETIC EVIDENCE, PARTIAL TRISOMY, ORIGIN, TRANSFORMATION, RECURRENCE, TRANSMISSION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Despite its rarity, donor cell leukemia (DCL) is a most intriguing entity. We report here the case of a 5 year-old girl with juvenile myelomonocytic leukemia and normal female karyotype who developed acute myeloblastic leukemia with a karyotype of 46, X, t(X; 7) (p21; p11.2), der(7) t(3; 7) (q13.3; q22) 5 months after peripheral blood hematopoietic stem cell transplantation from her HLA-matched sister. We performed the analysis of short tandem repeat sequence markers to DNA obtained from donor peripheral blood, patient's peripheral blood including leukemic blasts and patient's hair root. This analysis showed that the leukemic blood DNA matched the donor blood DNA and not the patient's DNA, thus confirming DCL. To our knowledge, this is the first case of DCL after peripheral blood SCT for juvenile myelomonocytic leukemia.