The effect of hydrogen peroxide in human internal thoracic arteries: Role of potassium channels, nitric oxide and cyclooxygenase products

Nacitarhan C., Bayram Z., Eksert B., Usta C., Golbasi I., Ozdem S. S.

CARDIOVASCULAR DRUGS AND THERAPY, cilt.21, sa.4, ss.257-262, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10557-007-6037-z
  • Dergi Adı: CARDIOVASCULAR DRUGS AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.257-262
  • Anahtar Kelimeler: arterial grafts, hydrogen peroxide, nitric oxide, potassium channels, prostaglandins, thoracic artery, ENDOTHELIUM-DEPENDENT RELAXATION, RAT AORTA, HYPERPOLARIZING FACTOR, K+ CHANNELS, MECHANISMS, INVOLVEMENT
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction We investigated both the effect and the role(s) of potassium channels, nitric oxide ( NO) and cyclooxygenase ( COX) products in the effect of hydrogen peroxide (H2O2) in human internal thoracic artery ( ITA) rings. Materials and methods Samples of redundant ITA obtained from patients undergoing a coronary artery bypass graft surgery were cut into 3 mm wide rings and suspended in 20 ml organ baths. Isometric tension was continuously measured with an isometric force transducer connected to a computer-based data acquisition system.