The relationship between prognosis of patients with traumatic brain injury and microRNA biogenesis proteins

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Yoldaş Ş. B., Sanlı S. H., Çabukusta Acar A., Sarıönder Gencer E., Aycan İ. Ö.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI, cilt.29, sa.11, ss.1228-1236, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 11
  • Basım Tarihi: 2023
  • Doi Numarası: 10.14744/tjtes.2023.54859
  • Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, MEDLINE
  • Sayfa Sayıları: ss.1228-1236
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: This study aims to investigate whether the expression levels of proteins involved in microRNA (miRNA) biogenesis vary in the early- and late-stage traumatic brain injury (TBI) patients and to evaluate its effect on prognosis.

Methods: Dicer, Drosha, DiGeorge Syndrome Critical Region 8 (DGCR8), Exportin5 (XPO5), and Argonaute2 (AGO2) levels were measured in the blood samples of severe TBI patients collected 4 to 6 hours and 72 hours after the trauma and compared with the control group. Prognostic follow-up of the patients was performed using the Glasgow Coma Scale score.

Results: There were no statistically significant changes in the expression of the miRNA biogenesis proteins Dicer, Drosha, DGCR8, XPO5, and AGO2 in patients with severe TBI. However, the expression of Dicer increased in the patients who improved from the severe TBI grade to the mild TBI grade, and the expression of AGO2 decreased in most of these patients. The Dicer expression profile was found to increase in patients discharged from the intensive care unit in a short time.

Conclusion: MicroRNAs and their biogenesis proteins may guide prognostic and therapeutic decisions for patients with TBI in the future.

 

Keywords: Traumatic brain injury, Prognosis, microRNA, microRNA biogenesis