The effects of cadmium and experimental diabetes on VEP spectral data and lipid peroxidation

Yargicoglu P., Agar A., Edremitlioglu M., Kara C.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.93, sa.1-2, ss.63-74, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 1-2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.3109/00207459808986413
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.63-74
  • Anahtar Kelimeler: cadmium, diabetes, VEP, TEARS, spectral analysis, rat, VISUAL-EVOKED-POTENTIALS, RED-CELL LIPIDS, GROWING-RATS, VITAMIN-E, MELLITUS, AUTOXIDATION, EXPOSURE, SERUM, BLOOD, BRAIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Fifty-two healthy swiss male albino rats, aged three months were used in this study. They were divided into four groups: Control (C), diabetic (D), Cadmium (Cd) and diabetic + Cadmium (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 i.p. (2 mg/kg/week). At the end of the two months of experimental period, flash visual evoked potentials (FVEPs) of four groups were recorded and amplitude spectral analysis was computed by transient response-frequency characteristics (TRFC) method. Significant amplitude decrement was found in 2-4 Hz frequency band of D + Cd group in comparison with C group. On the other hand, our data showed that Cd treatment and diabetic condition caused a significant increase of lipid peroxidation in kidney, brain, retina and lens.