Potentiation of antinociceptive effects of Lignocain by calcium channel blockers in spinal anaesthesia in rabbits

Sahin N., KARA H., Aydogdu T., Ertug Z., ERMAN M., İÇEL E.

7th International Symposium on the Pain Clinic, İstanbul, Türkiye, 2 - 06 Ekim 1996, ss.65-70 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.65-70
  • Akdeniz Üniversitesi Adresli: Evet

Özet

L-type calcium channels blockers binding sites are located in the dorsal horn where this place have an important role on processing noxious information. The purpose of this study was desingned to investigate the effects of verapamil on the antinociception and motor block of lignocain at the level of the spinal cord in rabbits. In our studies we found that intrathecal administration of calcium channel blocker(verapamil) did not show any antinociception. But co-application of local anesthetic and calcium channel blockers there was synergistic effect statistically not significant.
Abstract

L-type calcium channels blockers binding sites are located in the dorsal horn where this place have an important role on processing noxious information. The purpose of this study was desingned to investigate the effects of verapamil on the antinociception and motor block of lignocain at the level of the spinal cord in rabbits. In our studies we found that intrathecal administration of calcium channel blocker(verapamil) did not show any antinociception. But co-application of local anesthetic and calcium channel blockers there was synergistic effect statistically not significant