The efficacy of intravenous immunoglobulin on lipopolysaccharide-induced fetal brain inflammation in preterm rats

INCI A., UNAL D. S., OZES N. O., ERİN N., Akcakus M., OYGÜR N.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, cilt.209, sa.4, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 209 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.ajog.2013.06.027
  • Dergi Adı: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: inflammation, interleukin-1 beta (IL-1 beta), intravenous immunoglobulin (IVIG), lipopolysaccharide, NECROSIS-FACTOR-ALPHA, WHITE-MATTER INJURY, INTERLEUKIN-1 RECEPTOR ANTAGONIST, INTRAUTERINE INFLAMMATION, EXPERIMENTAL-MODEL, CEREBRAL-PALSY, AMNIOTIC-FLUID, MATERNAL INFECTION, HYPOXIC ISCHEMIA, TNF-ALPHA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Interleukin-1 is accepted as one of the major cytokines; it is involved in inflammatory processes and systemic fetal inflammatory response that is triggered by maternal lipopolysaccharide (LPS) injection. Because it is an antiinflammatory agent, we investigated (in the brain damage of rat pups) the role of intravenous immunoglobulin (IVIG) in decreasing interleukin-1 beta (IL-1 beta) expression and caspase 3 activity that was induced by maternal LPS administration.