The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson's disease

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Acar N., Parlak H., Ozkan A., Soylu H., Avcı S., Üstünel İ., ...Daha Fazla

TISSUE & CELL, cilt.56, ss.41-51, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.tice.2018.12.002
  • Dergi Adı: TISSUE & CELL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-51
  • Anahtar Kelimeler: DHA, Parkinson, Apelin, Cerebrum, Cerebellum, Pons, ESSENTIAL FATTY-ACIDS, LOCUS-COERULEUS, EICOSAPENTAENOIC ACID, PROTECTIVE MECHANISM, LIPID-PEROXIDATION, SUBSTANTIA-NIGRA, OXIDATIVE STRESS, MOTOR DEFICITS, CELL-SURVIVAL, AMYLOID-BETA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Parkinson's disease (PD) is a degenerative disorder of the human central and peripheral nervous systems. n-3 fatty acids docosahexaenoic acid (DHA, C22: 6n-3) and eicosapentaenoic acid (EPA) as well as apelin have anti-inflammatory effects in various cells. At the same time, apelin has anti-oxidative and anti-apoptotic effects. The study was conducted to determine the effect of DHA on the distribution of apelin and apelin receptor (APJ) in the central nervous system in 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP)-induced PD model.