Molecular determinants of the meiotic arrests in mammalian oocytes at different stages of maturation

ÖZTÜRK S.

CELL CYCLE, cilt.21, sa.6, ss.547-571, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/15384101.2022.2026704
  • Dergi Adı: CELL CYCLE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.547-571
  • Anahtar Kelimeler: Oocyte arrest, permanent arrest, meiotic maturation, gene expression, female infertility, developmental arrest, ACTIVATED PROTEIN-KINASE, SPINDLE ASSEMBLY CHECKPOINT, IN-VITRO MATURATION, CELL-CYCLE PROGRESSION, METAPHASE-II ARREST, 1ST POLAR BODY, MOUSE OOCYTE, GERMINAL VESICLE, DEVELOPMENTAL COMPETENCE, PROMOTING FACTOR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Mammalian oocytes undergo two rounds of developmental arrest during maturation: at the diplotene of the first meiotic prophase and metaphase of the second meiosis. These arrests are strictly regulated by follicular cells temporally producing the secondary messengers, cAMP and cGMP, and other factors to regulate maturation promoting factor (composed of cyclin B1 and cyclin-dependent kinase 1) levels in the oocytes. Out of these normally appearing developmental arrests, permanent arrests may occur in the oocytes at germinal vesicle (GV), metaphase I (MI), or metaphase II (MII) stage. This issue may arise from absence or altered expression of the oocyte-related genes playing key roles in nuclear and cytoplasmic maturation. Additionally, the assisted reproductive technology (ART) applications such as ovarian stimulation and in vitro culture conditions both of which harbor various types of chemical agents may contribute to forming the permanent arrests. In this review, the molecular determinants of developmental and permanent arrests occurring in the mammalian oocytes are comprehensively evaluated in the light of current knowledge. As number of permanently arrested oocytes at different stages is increasing in ART centers, potential approaches for inducing permanent arrests to obtain competent oocytes are discussed.