Hyperglycaemia-induced subcellular redistribution of GLUT1 glucose transporters in cultured human term placental trophoblast cells

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Hahn T., Hahn D., Blaschitz A., Korgun E. T., Desoye G., Dohr G.

DIABETOLOGIA, cilt.43, sa.2, ss.173-180, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s001250050026
  • Dergi Adı: DIABETOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.173-180
  • Anahtar Kelimeler: GLUT1, translocation, glucose, transport, hyperglycaemia, diabetes, trophoblast, placenta, pregnancy, electron microscopy, INSULIN-INDUCED TRANSLOCATION, 3T3-L1 ADIPOCYTES, PLASMA-MEMBRANE, SKELETAL-MUSCLE, ADIPOSE-CELLS, IN-VITRO, RAT, LOCALIZATION, ISOFORMS, TRAFFICKING
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aims/hypothesis. We have recently shown that hyperglycaemia down-regulates the GLUT1 glucose transport system of term placental trophoblast. The reduction in GLUT1 protein alone was, however, not sufficient to explain the decrease in net glucose uptake, suggesting additional mechanisms. Therefore, we hypothesised that hyperglycaemia in vitro leads to a GLUT1 translocation from the trophoblast surface to intracellular sites.