Chronic toxicity of pesticides to the mRNA expression levels of metallothioneins and cytochrome P450 1A genes in rainbow trout

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Ceyhun S. B., Aksakal E., Kirim B., Atabeyoglu K., Erdoğan O.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.28, sa.2, ss.162-169, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/0748233711409482
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.162-169
  • Anahtar Kelimeler: MTs, CYP-450, deltamethrin, DDVP, Oncorhynchus mykiss, FLOUNDER PLATICHTHYS-FLESUS, OXIDATIVE STRESS, IN-VITRO, ONCORHYNCHUS-MYKISS, CARBONIC-ANHYDRASE, AH RECEPTOR, DNA-DAMAGE, INDUCTION, LIVER, ERYTHROCYTES
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

The hazardous effects of pesticides on various metabolic pathways are a great problem for environmental health and should be well determined. In the present study, the authors treated rainbow trout with 0.6 mu g/L deltamethrin for 28 days and 1.6 mg/L 2,2-dichlorovinyl dimethyl phosphate for 21 days. After this time period, the authors observed alterations in mRNA expression levels of MT-A, MT-B and CYP-1A. Chronic exposure to low levels of pesticides may have a more significant effect on fish populations than acute poisoning. While both pesticides caused a significant increase on mRNA levels of MT-A and CYP-1A, MT-B mRNA levels were increased significantly only upon deltamethin administration. The significant increase in mRNA levels of the corresponding genes may be considered as a defence mechanism in addition to the antioxidants against oxidative stress, as well as a detoxification mechanism against adverse effects of pesticides.