INTERNATIONAL JOURNAL OF UROLOGY, cilt.83, sa.4, ss.75-79, 2009 (SCI-Expanded)
Introduction: To investigate the effect of tadalafil on Resistivity Index (RI) and Pulsatility Index (PI) in partial unilateral ureteral obstruction (PUUO). Methods: Twelve New Zealand rabbits were assigned into two groups. Baseline renal
Doppler ultrasonography (USG) was performed in all rabbits. The rabbits in group 1 received tadalafil for a month (10
mg/72 h) and group 2 was defined as sham. After 1 month,
in both groups left PUUO was created. Renal Doppler USG
was performed to measure RI and PI parameters of both kidneys on the 4th hour and 1st and 3rd days postoperatively.
Results: Baseline renal Doppler USG revealed that there was
no difference between two kidneys in both groups. The differences in mean RI and PI values of the kidneys between the
sham and tadalafil groups were not statistically significant.
Compared with the preoperative values, postoperative RI
and PI values for the left kidneys were significantly increased
in the period from 4 h to 3 days postoperatively in the sham
group (p ! 0.05). However, mean RI and PI values were not
increased in the tadalafil group when compared with the sham group and this difference between the two groups
was significant (p ! 0.05). Conclusions: Tadalafil has a lowering affect on RI and PI in experimentally created PUUO.