Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation

Canpolat M., Mourant J.

Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, San-Jose, Kostarika, 25 - 26 Ocak 2000, cilt.3911, ss.10-18 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 3911
  • Doi Numarası: 10.1117/12.384915
  • Basıldığı Şehir: San-Jose
  • Basıldığı Ülke: Kostarika
  • Sayfa Sayıları: ss.10-18
  • Anahtar Kelimeler: photodynamic therapy, photosensitizer concentration, minimally invasive measurements, OPTIMIZING LIGHT DOSIMETRY, FLUORESCENCE SPECTROSCOPY, PHOTODYNAMIC THERAPY, SPECTRA, TISSUE, MEDIA
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

We present a novel minimally invasive method to measure the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescence Light using a steady state fluorescence spectrometer. The ratio of the fluorescence to scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation, therefore the measurements could be performed through the working channel of an endoscope.