The Arg753GIn polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

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Ogus A., Yoldas B., Ozdemir T., Uguz A., Olcen S., Keser I., ...Daha Fazla

EUROPEAN RESPIRATORY JOURNAL, cilt.23, sa.2, ss.219-223, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1183/09031936.03.00061703
  • Dergi Adı: EUROPEAN RESPIRATORY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-223
  • Anahtar Kelimeler: immunity, polymorphism, Toll-like receptor, tuberculosis, INTERFERON-GAMMA-RECEPTOR, MYCOBACTERIUM-TUBERCULOSIS, CELLULAR ACTIVATION, LEPROMATOUS LEPROSY, CALMETTE-GUERIN, CUTTING EDGE, INFECTION, SUSCEPTIBILITY, MUTATION, IMMUNITY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Toll-like receptor 2 (TLR2), a member of the Toll-like receptor family, plays an important role in recognition of, and subsequent immune response activation against, mycobacteria. The genetic polymorphism of TLR2 (arginine to glutamine substitution at residue 753 (Arg753Gln)) has been associated with a negative influence on TLR2 function, which may, in turn, determine the innate host response to mycobacteria. The aim of the present study was to investigate the Arg753Gln single nucleotide polymorphism of the TLR2 gene in tuberculosis (TB) patients compared to healthy controls.