Substance P and vasoactive intestinal peptide levels in middle ear effusions of children

EYIGOR H., OSMA U., YILMAZ M. D., EYİGÖR M., Gultekin M., ERİN N.

ACTA OTO-LARYNGOLOGICA, cilt.132, sa.10, ss.1036-1041, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 10
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/00016489.2012.680981
  • Dergi Adı: ACTA OTO-LARYNGOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1036-1041
  • Anahtar Kelimeler: Serous effusion, mucoid effusion, otitis media with effusion, OTITIS-MEDIA, CAPSAICIN PRETREATMENT, NEUROPEPTIDES, INFLAMMATION, POLYPEPTIDE, RECEPTORS, RAT, VIP, AGE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Conclusion: This is the first report demonstrating high levels of substance P (SP) that inversely correlate with vasoactive intestinal peptide (VIP) levels in middle ear effusions (MEEs) of patients with otitis media with effusion (OME). Increased SP and decreased VIP levels might play a role in the pathogenesis of chronic OME. Objective: The etiology of OME is multifactorial, and neurogenic inflammation may play a significant role. SP and VIP levels were not evaluated previously in MEEs of children with OME. Methods: Fifty patients aged 2-12 years (mean age 5.24 +/- 2.64) were included in the study. MEEs were classified as mucoid or serous based on the gross appearance. SP and VIP levels were determined using ELISA. Results: High levels of SP were detected in MEEs. In addition SP levels were significantly higher in serous samples (2910.55 +/- 307.96 vs 2218.55 +/- 262.30 pg/ml). There were also age-dependent changes, such that SP levels were significantly higher in children aged 2-3 years compared with those who were 4-5 and 6-12 years old. VIP levels were undetectable in 30% of patients and the mean level of VIP was 50.91 +/- 16.01 pg/ml in serous middle ear effusions and 54.86 +/- 15.91 pg/ml in mucoid MEEs.