Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update

Ozben T.

CURRENT TOPICS IN MEDICINAL CHEMISTRY, cilt.15, sa.2, ss.170-178, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1568026615666141209160918
  • Dergi Adı: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.170-178
  • Anahtar Kelimeler: Antioxidants, Cancer, Chemotherapeutic agents, Oxidative stress, Radiation, Reactive oxygen species, Supplements, BETA-CAROTENE SUPPLEMENTATION, LONG-TERM SUPPLEMENTATION, INDUCED OXIDATIVE STRESS, ACETYL-L-CYSTEINE, 5-YEAR FOLLOW-UP, CELL LUNG-CANCER, ALPHA-TOCOPHEROL, PROSTATE-CANCER, VITAMIN-E, CARDIOVASCULAR-DISEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death. Antioxidant supplements are consumed widely by cancer patients in order to prevent toxic side effects of cancer treatment to normal tissues and organs. However, the effects of antioxidant supplementation in cancer therapy were largely disappointing. There is still no consensus on the efficacy and safety of dietary antioxidant supplementation during conventional cancer therapy. In some studies, antioxidant supplements did not reduce the risk for cancer or prevent tumour growth; at the contrary, these interventions resulted in some cases to be harmful to the patients. Therefore, a guidance on antioxidant supplementation based on large clinical trials is urgently needed in order to obtain the best possible care and to avoid risky treatments for cancer patients.