THE EFFECT OF HEME OXYGENASE INHIBITION ON VISUAL EVOKED POTENTIALS

Savcioglu F., Akpinar D., Yargicoglu P., Agar A.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.119, sa.9, ss.1384-1398, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119 Sayı: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00207450902961950
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1384-1398
  • Anahtar Kelimeler: heme oxygenase-2, heme oxgenase inhibition, tin protoporphyrin IX, LONG-TERM POTENTIATION, CARBON-MONOXIDE, BLOOD-FLOW, TIN-PROTOPORPHYRIN, NITRIC-OXIDE, RAT, GENE, LOCALIZATION, EXPRESSION, PATHWAY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This study investigated the effect of heme oxygenase (HO) inhibition on visual evoked potentials (VEPs). HO catalyzes the oxidative degradation of heme. Products of HO reaction are biliverdin, ferrous iron, and carbon monoxide (CO). CO is a signal molecule and is an endogenous modulator in the soluble guanylate cyclase/cyclic guanosine monophosphate signaling pathway. Rats were treated with HO inhibitors tin protoporphyrin IX (SnPP IX) or zinc protoporphyrin IX (ZnPP IX) or HO inducer sodium arsenite (Na-arsenite). Soluble guanylate cyclase is inhibited by 1H-[1,2,3]oxydiazolo[4,3-a]quinoxalin-1-one (ODQ) and induced by 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1). VEPs were recorded under mild ether anesthesia with the help of stainless steel subdermal electrodes and a photic stimulator. SnPP IX, ODQ or SnPP IX + YC-1 injections significantly prolonged latencies of P3; however, Na-arsenite shortened latency of P3. It has been shown that HO affects VEPs.