Mechanisms and strategies to overcome multiple drug resistance in cancer

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Ozben T.

FEBS LETTERS, cilt.580, sa.12, ss.2903-2909, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 580 Sayı: 12
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.febslet.2006.02.020
  • Dergi Adı: FEBS LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2903-2909
  • Anahtar Kelimeler: multidrug resistance, ATP-binding cassette transporters, cancer chemotherapy, multidrug resistance inhibitors, MEDIATED MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, GLUCOSYLCERAMIDE SYNTHASE, CERAMIDE GLYCOSYLATION, ADRIAMYCIN RESISTANCE, CELL-LINE, TRANSPORTER, DOXORUBICIN, METABOLISM, MODULATOR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

One of the major problems in chemotherapy is multidrug resistance (MDR) against anticancer drugs. ATP-binding cassette (ABC) transporters are a family of proteins that mediate MDR via ATP-dependent drug efflux pumps. Many MDR inhibitors have been identified, but none of them have been proven clinically useful without side effects. Efforts continue to discover not toxic MDR inhibitors which lack pharmacokinetic interactions with anticancer drugs. Novel approaches have also been designed to inhibit or circumvent MDR. In this review, the structure and function of ABC transporters and development of MDR inhibitors are described briefly including various approaches to suppress MDR mechanisms. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.