Biochemical markers of bone metabolism in children with Helicobacter pylori infection

Ozdem S., Akcam M., Yilmaz A., Gultekin M., Artan R.

DIGESTIVE DISEASES AND SCIENCES, cilt.52, sa.4, ss.967-972, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10620-006-9292-0
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.967-972
  • Anahtar Kelimeler: bone markers, children, ferritin, Helicobacter pylori, osteoporosis, vitamin B12, TUMOR-NECROSIS-FACTOR, CYTOKINE EXPRESSION, GASTRIC-CARCINOMA, SUBNORMAL GROWTH, IRON-DEFICIENCY, OSTEOPOROSIS, ASSOCIATION, POPULATION, INTERLEUKIN-8, PREVALENCE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8 +/- 3 years). Serum levels of intact parathyroid hormone, beta-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (-) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(-) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.