Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin

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Ercan S., Kencebay C., Basaranlar G., Ozcan F., DERİN N., Aslan M.

LIPIDS IN HEALTH AND DISEASE, cilt.14, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1186/s12944-015-0008-3
  • Dergi Adı: LIPIDS IN HEALTH AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Sodium metabisulfite, Ghrelin, Polyunsaturated fatty acids, POLYUNSATURATED FATTY-ACIDS, ANTIOXIDANT ENZYME-ACTIVITY, VISUAL-EVOKED POTENTIALS, INDUCED OXIDATIVE STRESS, ALVEOLAR MACROPHAGES, LIPID MEDIATORS, SULFUR-DIOXIDE, S-SULFONATES, SULFITE, PLASMA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Sodium metabisulfite is commonly used as preservative in foods but can oxidize to sulfite radicals initiating molecular oxidation. Ghrelin is a peptide hormone primarily produced in the stomach and has anti-inflammatory effects in many organs. This study aimed to assess endogenous omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) in rat peripheral organs following sodium metabisulfite treatment and determine the possible effect of ghrelin on changes in n-6 inflammatory pathway.