Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson's disease

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PARLAK H., Ozkan A., Dilmac S., TANRIÖVER G., ÖZSOY Ö., Agar A.

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, cilt.56, sa.1, ss.27-37, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5603/fhc.a2018.0005
  • Dergi Adı: FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-37
  • Anahtar Kelimeler: Parkinson's disease, mice, protection, MPTP, DHA, nNOS phosphorylation, lipid peroxidation, caspase-3, VISUAL-EVOKED POTENTIALS, MOUSE MODEL, LIPID-PEROXIDATION, OXIDATIVE STRESS, MOTOR DEFICITS, ALPHA, ACTIVATION, INFLAMMATION, INHIBITION, 6-OHDA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction. Docosahexaenoic acid (DHA) has been shown to have beneficial effects on Parkinson's disease (PD). The aim of this study was to investigate if the DHA acts on neurons of substantia nigra (SN) by phosphorylation of neuronal nitric oxide synthase (nNOS) in an experimental mouse model of PD.