Analysis of serum cytokine levels in larynx squamous cell carcinoma and dysplasia patients.

EYİGÖR M., EYIGOR H., OSMA U., YILMAZ M. D., ERİN N., SELCUK O. T., ...Daha Fazla

Iranian journal of immunology : IJI, cilt.11, sa.4, ss.259-68, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 4
  • Basım Tarihi: 2014
  • Dergi Adı: Iranian journal of immunology : IJI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.259-68
  • Anahtar Kelimeler: Bead Array, Cytokine, Dysplasia, HNSCC, Larynxm Carcinoma, NECK-CANCER, BRONCHOPULMONARY DYSPLASIA, HEAD, INTERLEUKIN-6, SURVIVAL, ROLES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) levels. Additionally, IL-8 levels were determined through ELISA. Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p<0.05). IL-8 and IL-10 levels were also higher in SCC patients than dysplasia patients (p<0.05). Additionally, IL-6 and IL-10 were all found to be markedly increased in dysplasia patients compared with controls (p<0.05). Conclusion: Our results demonstrate an imbalance of IL-6 and IL-10 not only in HNSCC but also in laryngeal dysplasia.